In the 1980s, the influence of free radicals on health was increasingly recognized by people. Modern medicine and nutrition and health sciences believe that free radicals can directly cause many diseases in the human body, and are also related to the occurrence of other diseases. The Graduate School of the French Academy of Sciences once made grapes. Seed extract proanthocyanidins scavenge free radical activity experiments, the results suggest that grape seed extract proanthocyanidins is one of the most potent and effective free radical scavengers found so far. In particular, its in vivo activity is unmatched by other antioxidants. Bagchi .D used mice for in vivo experiments with grape seed extract proanthocyanidin, VC, VE, and β-carotene to induce TPA (12-O-mycthlfovar-13-acetate) liver, The protective effects of lipid peroxidation in brain tissue were compared and it was found that the grape seed extract proanthocyanidins, VC, VE, and β-carotene all reduced TPA-induced reactive oxygen species at a dose of 100 mg/kg BW. The reduction rate of phagocyte luminescence was respectively 70%, 18%, 47% and 16%. The reduction rates using cytochrome reduction were 65%, 15%, 37% and 19% respectively. It was also found that grape seed extract procyanidins were Inhibition of TPA-induced production of reactive oxygen species in peritoneal macrophages has a dose-response relationship. The results show that grape seed extract procyanidins can protect against oxidative damage. And its protective effect is better than other antioxidants. In addition, similar results were obtained in in vitro experiments with Bagchi.D. The authors used chemiluminescence and cytochrome C reduction methods to determine the scavenging superoxide anion radicals of grape seed extracts procyanidins, VC, VE, β-carotene, superoxide dismutase, catalase, and mannitol. The ability of hydroxyl radicals. The results showed that the inhibition of free radicals by the proanthocyanidins of grape seed extract had a concentration-response relationship. At a concentration of 100 mg/L, the inhibitory capacity of proanthocyanidins of grape seed extract on superoxide anions and hydroxyl radicals was 78% and 81%. Under the same conditions, the ability of Vc to inhibit the above two kinds of free radicals was 12% and 19%, VE was 50% and 75%, and the combined ability of superoxide dismutase and catalase to inhibit superoxide anion was about 83%. The ability of mannitol to inhibit hydroxyl radicals was 87%, suggesting that grape seed extract procyanidins is a stronger free radical scavenger than VC and VE. Protecting Cardiovascular and Preventing Hypertension Grape seed extract proanthocyanidins are used to increase blood vessel resistance and reduce capillary permeability. Its antioxidant and anti-enzymatic actions have been demonstrated by several in vivo test models that improve capillary permeability.
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